The opera singer Enriqueta Guardia was born in Jaén. Her father, Vicente Guardia, owned two musical instrument stores near the city's Conservatory of Music. In 1910, the family moved to Madrid, where Enriqueta continued her musical studies with her sisters. They began receiving singing and operatic declamation lessons under the tutelage of Maestro Tabuyo. That same year, taking an external examination, she gained admission with outstanding marks to the Royal Conservatory of Madrid. The following year, along with her sisters Milagros and Pepita, she debuted in a concert at the Crystal Palace in the Retiro Park for the Decorative Arts Exhibition, and on November 2nd of that year, she was hired by the Teatro Real, where she remained on the payroll for four seasons, until 1916. On Christmas Eve of that year, she gave a concert in the halls of the CBA alongside Polish pianist Carolina Peczenik, with Tomás de León as piano accompanist. Their repertoire includes compositions by Brahms, Rossini, Donizetti, Chopin, Albéniz, and Tabuyo, among others. 

After a long and successful career as a singer, which she combined with teaching, giving private lessons at home with her sister Milagros, in 1942, she proposed to Pascual Marquina that they reopen a singing and solfège academy in the Círculo de Bellas Artes. Being president del Círculo Marceliano Santamaría, the Board of Directors approved his hiring on January 27, 1942. Both sisters were the singing and solfège teachers of the entity until their retirement in 1951.